It is reported that the registration number of Lianhua Qingwen Capsules in the Philippines is THPR-50 and the product category is traditional herbal drugs. 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How to take it to realize the maximal efficacy? (For Children 4 to 18 years of age): 3 times daily. Lianhua Qingwen Launched in the Philippines - Business The course of treatment is 7-10 days for patients with mild and moderate COVID-19. Bias in. Get new journal Tables of Contents sent right to your email inbox, http://creativecommons.org/licenses/by/4.0, Http://www.nhc.gov.cn/jkj/s7916/202001/44a3b8245e8049d2837a4f27529cd386.sht-ml, https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-, http://www.nhc.gov.cn/yzygj/s7653p/202002/8334a8326dd. Here, we chose a thirteen-component TCM formula, Lianhua Qingwen capsule (LHQW), as a eCollection 2020. Lianhua Qingwen The Chinese medicine compound Lianhua Qingwen has been listed as the recommended drug for the diagnosis and treatment of respiratory infectious diseases by the national Wei Jian administration and the State Administration of traditional Chinese medicine for 20 times. In 2012, Prevention and Treatment Scheme of Traditional Chinese Medicine for Type B Influenza, issued by the State Administration of Traditional Chinese Medicine Already have Rappler+? A park employee (R), seen wearing goggles and face mask, walks in a park in Beijing on March 14, 2020. Announcement of the national health and Health Commission of the people's Republic of China [EB /OL] (2020-01-20) [20200217]. The Chinese embassy in the Philippines announced this on Wednesday, August 12, hailing it as an important progress in the entry of TCM products into the Philippine market.. If substantial heterogeneity is identified, we will report it and explore possible causes using sensitivity analysis and subgroup analysis. Lianhua Qingwen (LHQW), a Chinese supplement approved by the Philippine Food and Drug Administration (FDA) for mild Covid-19 symptoms, continues to All randomized controlled trials (RCTs), Retrospective cohort study (RCSs), Comparison before and after the study (BAs) of Lianhua Qingwen combined with Conventional antiviral Western Medicine for COVID-19 will be included. SHIJIAZHUANG YILING PHARMACEUTICAL CO., LTD. Lianhua Qingwen, a representative TCM patent product for the treatment of influenza. Lianhua Qingwen (LHQW) [33] Previous pharmacodynamic studies have confirmed that Lianhua Qingwen capsule can significantly inhibit the SARS CoV virus in cultured cells in vitro, and has a significant inhibitory effect on H1N1, H3N2, h7n9, and other influenza viruses,[3436] indicating that Lianhua Qingwen capsule has played an important role in the prevention and control of public health events of respiratory system caused by virus. [31]. [Functions and Indications]Clear heat and detoxify, remove lung hotness. BBD Aug 2024. The results will be cross-checked by the 2 reviewers, and any disagreements will be resolved by consensus, with any ongoing differences in opinion being arbitrated by a third reviewer (LMJ). ACTSmarket.com is the e-shop and distribution arm of ACTSmarket Ltd, 7. [2]. Would you like email updates of new search results? There are no comments yet. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Because the epidemic situation is still ongoing, there are still clinical studies in progress. However, this systematic review will have some limitations. 2.Its not appropriate to take nourishing chinese medicine wihte taking medicine. [3]. Should not be used for wind-cold common cold. All the prescriptions are used to clear the toxic heat in the lung, clear the lung qi, and cut off the disease. Avoid alcohol and tobacco and spicy,cold, greasy food during taking this product. eCollection 2023. Web[Administration and Dosage] For oral administration, 4 capsules once, 3 times a day. Clinical observation shows that the total effective rate of traditional Chinese medicine is >90%.[15]. High heterogeneity may also arise from the various evaluations. Hongying Mo, Zifeng Yang, Jinping Zheng, et al. 8600 Rockville Pike Choosing a selection results in a full page refresh. 5.Children, preganant or lactation women,elderly ,feeble and weak patients ,spleen and stomach weakness patients should be taken under the guidance of physician. Select all eligible studies published before May 8, 2020. [Administration and Dosage] COVID-19; Lianhua Qingwen; meta-analysis; protocol; systematic review. If I2 test <50%, a fixed-effects model will be used to pool the data. See this image and copyright information in PMC. The site is secure. It has important clinical significance for alleviating the severity of COVID-19 and shortening the course of disease. It has been recommended as a recommended drug for the diagnosis and treatment of pneumonia caused by a new coronavirus (which has been included in the fifth, sixth, and seventh edition of the diagnostic and therapeutic plan version). Bioinform Biol Insights. Buy two get one free promotion. [31] The results will be interpreted carefully based on several explanations for funnel plot asymmetry. [3] It is reported that 4,430,100 cases have been confirmed in the world, and 299,451 cases have died. DC and QZ developed the search strategy. [Main Ingredients] Shunya Zhu, Xiaoying Li, Yunling Wei, et al. [Contraindications]Those who are allergic to this product and its ingredients should not take it. The Philippines Food and Drug Administration (FDA) has approved the traditional Chinese medicine (TCM) capsule Lianhua Qingwen widely used in China as Stage Food and Drug Administration Approval number:Z20040063. Used in the patterns of heat toxin assailing the lung in influenza, manifested as fever or high fever, aversion to cold, muscular soreness, stuffy and runny nose, cough, headache, dry and sore throat, reddish tongue, yellow or yellow and greasy tongue coating. Lianhua LHQW is approved by China'sNational TCM Administration for the treatment of mild covid-19. The protocol will be disseminated in a peer-reviewed journal or presented at a relevant conference. Published by Wolters Kluwer Health, Inc. 1. general information: title, authors, year of publication, and Study area, average age, average course of disease and treatment time; 2. trial characteristics: design, duration of follow-up, method of randomization, allocation concealment, incomplete outcome data, blinding (patients, people administering treatment, outcome assessors); 3. intervention(s): intervention(s) (The dosage form of. When the dose was administered at 150, 300, and 600 g/mL, it significantly inhibited the expression of SARS-CoV-2 in a dose-dependent manner, and inhibited the formation of plaques in virus-infected cells, confirming that Lianhua Qingwen significantly inhibited SARS-CoV-2 activity in vitro. In addition, it can also interact with other compounds and herbs. XLZ and JNL will assess the risk of bias and perform data synthesis. a non-profit social enterprise that collaborates with other SE producers to build capacity in marketing, sales and operations. Ephedra increases heartbeat and blood pressure. Also excluded are studies enrolling <30 participants. Web[Strength] 0.35g/capsule [Administration and Dosage] For oral administration, 4 capsules once, 3 times daily [Adverse Reactions] Unclear [Contraindications] Unclear [Precautions] 1. The PRISMA-P (Preferred Reporting Items for Systematic review and Meta-Analysis Protocols) checklist of this protocol is presented in PRISMA-P checklist. 9. For the treatment of COVID-19, the main effects of Lianhua Qingwen are as follows: First, after taking the capsule, patients' symptoms improve quickly, two days earlier than the control group. Second, CT scan result also shows that patients recover faster than the control group. Third, the capsule can shorten fever time. WHO Director-General's opening remarks at the media briefing on. Remdesivir in adults with severe, [13]. How to Use: Dosage: Consume orally 4 capsules each, 3 times daily after meal. [1014] Data showed that novel coronavirus pneumonia was confirmed in China, and 74,187 people used Chinese medicine, accounting for 91.5%, of which 61,449 in Hubei Province used Chinese medicine, accounting for 90.6%. If I2 test 50%, a random-effects model will be used for data analysis instead. Patients with body temperature higher than 38.5 should see the doctor. Yuewen Ding, Lijuan Zeng, Runfeng Li, et al. Individuals w/ cold deficiencies in spleen & stomach or w/ qi. At the same time, the single arm study was included in the analysis, not involved in data synthesis, only used to assist in displaying the clinical characteristics of the subjects, not for efficacy evaluation. The assessment will be adjudicated into 4 levels: high, moderate, low, or very low. It is compatible with Rhodiola to clear lung and remove blood stasis. Two reviewers (XLZ and JNL) will assess the eligibility of the studies retrieved during the searches independently using the inclusion and exclusion criteria. [24]. The 3 drugs and 3 parties in China have been effective in many countries around the world, and once again reveal the special advantages of the Chinese herbal medicine overall adjustment and multi target therapy, which suggests the application of Lianhua Qingwen granule. 2018;Beijing: Science and Technology Literature Press, 13271329. BackgroundLHQW's formulation is based on two ancient formulae from the Han and Qing dynasties - Maxing Shigan decoction and Yinqiao powder - following the SARS epidemic. Copyright Shijiazhuang Yiling Pharmaceutical Co,Ltd. In particular, theChinese herbma huang, scientifically known asEphedra sinica, is where the drug ephedrine is extracted from. A: Before treatment; B: After treatment. For patients showing mild symptoms, Lianhua Qingwen would be more effective. Higgins JPT, Thompson SG, Deeks JJ, et al. The clinical effective rate, CT improvement rate, and severe conversion rate will be assessed as the primary outcomes. Effect of Lianhuaqingwen Capsule on lung pathological injury and expression of inflammatory factors in mice induced by automobile exhaust [J]. Progress in pharmacology and clinical research of Lianhuaqingwen capsule [J]. 2011. Children should be administered under adults supervision. China's top respiratory expert,the leader of the high-level expert group of the National Health Commission, Zhong Nanshan said in a webinar with overseas Chinese students, Lianhua Qingwen capsule has been proven effective for the treatment of virus. The capsule was earlier developed in 2003 to treat the severe acute respiratory syndrome (SARS) and extracts the essence of 13 herbs. Click to view Lianhua Qingwen detailed prescribing information Overdosage View Lianhua Qingwen In 2010, Diagnosis and Treatment Scheme for Wind-warm Lung-heat Disease (Non-severe Community Acquired Pneumonia) (2010), issued by the Chinese Health Protection Committee and the State Administration of Traditional Chinese Medicine Please protect from moisture after opening the moisture proof bag. Accessibility Teresa May Bandiola is a licensed pharmacist, a published writer, and a university instructor. Ends on 31 July 2022. Chest radiographs of the patient. Cao B, Wang Y, Wen D, et al. If you are using other drugs, please consult your doctor before using this product. AChinese researchclaimsthat ithas been used for viral infections for more than a decade, includingSevere Acute Respiratory Syndrome (SARS)in 20022003. The clinical data of 66 early-mid-stage COVID-19 patients admitted to hospitals in Guangzhou between January 2020 and April 2020 were retrospectively analyzed. 11. 4.Patients with diabetes patients,high blood pressure, heart diseases, liver disease, kidney disease and other severe chronic diseases shall take medicine under guidance of physician. The study was financially supported by the National Natural Science Foundation of China (Grant Number 86174092) and a grant from the School construction project of State Administration of traditional Chinese medicine (Grant Number LPGZS22014-11). The Chinese embassy likewise advised the public to only purchase and consume authentic traditional Chinese medicine produced by qualified pharmaceutical manufacturers. Domingo said this version of the capsule was still unregistered to date, meaning the FDA could not guarantee its quality and safety. WebLianhua Qingwen Jiaonang with Chinese Characters; As per continuing post-marketing surveillance, there is still incessant sale and distribution even through social media platforms, such as Facebook, of Lianhua Qingwen Jiaonang with Chinese characters, which were verified as unregistered by the FDA. 2 capsules per dose. Lianhua Qingwen Dosage & Drug Information | MIMS Philippines Tips: Please read the directions for use in retail or directed by physician. The studies that do not fulfill the inclusion criteria will be excluded and listed with reasons for their exclusion. LHQW is not approved by Singapore's HSA for the prevention and treatment of Covid-19. The .gov means its official. Siwen Tang, Yanfen Zhang, Kejian Liu, et al. If meta-analysis is not applicable, we will conduct a systematic narrative synthesis providing information to summarize and explain the characteristics and findings of the included studies. We aim to assess the efficacy and safety of Lianhua Qingwen combined with Conventional antiviral Western Medicine in Clinical treatment of COVID-19 or asymptomatic infection. Children, pregnant women, nursing mother, senile and infirm patients or those with week spleen should take medicine under doctors direction. The following data will then be extracted from the studies selected for inclusion using a data collection form, and recorded onto an Excel file: first author and year, study design, sample, intervention, type of measures, risk of bias assessment, and findings. National Key New Product Whether a fixed-effects or a random-effects model will be used depends on the results of I2 test for heterogeneity. [12]. Clipboard, Search History, and several other advanced features are temporarily unavailable. Please try again soon. [19]. Chest radiographs. The independent Newcastle Ottawa scale was used to conduct methodological quality assessment of nonrandomized trials. Asia's one-stop resource for medical news, clinical reference and education, Click to view Lianhua Qingwen detailed prescribing information. Because the novel coronavirus pneumonia has not yet been completely subsided, more large-sample clinical studies are still ongoing. Chinese Journal of pharmacology and toxicology 2015;29:2137. Your message has been successfully sent to your colleague. If use with the other drugs at the same time may occur drug interactions,details please consult your physician or pharmacist. < 5 years: not recommended because it may be difficult for young children to swallow capsules. It is to systematically understand the curative effect of Lianhua Qingwen on the treatment of new crown pneumonia, and provide a reference for the design and follow-up work of the Chinese medicine compound Lianhua Qingwen in the global epidemic prevention and clinical trial design and follow-up work. Kunming: Kunming University of technology; 2015. Lianhua Qingwen prescription for Coronavirus disease Even if symptoms of fever, fatigue and cough end earlier, please continue to complete an 8-day course to help the body recover.For children younger than 14 years old, we recommend that you consult a TCM physician on the dosage since the body condition differs from each child. All data generated or analyzed during this study are included in this published article [and its supplementary information files]. Contraindicated for the patients allergic to this product, be cautions about patients with allergic constitution. All relevant data are within the article and its supporting information files. Meanwhile, China also provides technical solutions through long-distance video exchanges to share treatment experience with Japan, South Korea, Italy, the United States, Iran, Singapore, and so on. The patients receiving Lianhua Qingwen Capsule treatment were assigned to the observation group (n=33) and those given conventional therapy were included in the control group (n=33). Avoid cigarettes, alcohol and keep from eating spicy, raw, cold or greasy food. [59] In the early stage, there is no specific medicine or vaccine; the intervention of Chinese traditional medicine compound Lianhua Qingwen and other traditional Chinese medicine have played an important role. Lianhua Qingwen Jiangnan (LHQW) for Flu and Colds Use left/right arrows to navigate the slideshow or swipe left/right if using a mobile device. Coronavirus disease 2019 (, [5]. Correct way is to take it orally, 3 capsules 1 time, 3 times a In addition, only studies published in English and Chinese will be searched and included because of language barriers, so a language bias may exist. Wolters Kluwer Health cDepartment of lung diseases, the Third Clinical Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China. It includes forsythia, honeysuckle, ephedra (ma huang), armeniacae, gypsum, isatis, dryopteridis, houttuynia, pogostemon, rheum, rhodiola, Chinese peppermint (bohe), and liquorice. >10 to <14 years old: 3capsules x 3 times a day ( after breakfast, lunch and dinner).> 5 to <12 years old: 2 to 3 capsules x 3 times a day ( after breakfast, lunch and dinner). LHQW won the 2nd prize of the National Scientific and Technological Progress Award in 2011 for the treatment of influenza. https://news.cgtn.com/news/2020-04-16/Beijing-approves-TCM-drugs-for-COVID-19-PJWgGfRAQg/index.html. WebFor patients showing mild symptoms, Lianhua Qingwen would be more effective. [21]. Forsythiae Fructus, Lonicerae Japonicae Flos, Ephedrae Herba (processed with honey), Armeniacae Semen Amarum (stir-baked), Gypsum Fibrosum, Isatidis Radix, Dryopteridis Crassirhizomatis Rhizoma, Houttuyniae Herba, Pogostemonis Herba, Rhei Radix et Rhizoma, Rhodiolae Crenulatae Radix et Rhizoma, l-Menthol, Glycyrrhizae Radix et Rhizoma. Data synthesis reports the intervention effect of the original study by integrating the cohort study. MJL will arbitrate any disagreement and ensure that no errors occur during the review. It is used for temporary relief of shortness of breath, chest tightness, and wheezing due to bronchial asthma. Writing review & editing: Xiaolin Zhang. System searches CNKI, CBM, VIP and Wanfang databases, PubMed, EMBASE, MEDLINE, Cochrane central, and clinical trial registration centers, such as ChiCTR, NTR and clinical Trials.gov. How to cite this article: Zhang X, Cao D, Liu J, Zhang Q, Liu M. Efficacy and safety of Lianhua Qingwen combined with conventional antiviral Western Medicine in the treatment of coronavirus disease (covid-19) in 2019: Protocol for a systematic review and meta-analysis. Effect of aqueous extract of Lianhuaqingwen Capsule on bacterial biofilm of methicillin-resistant Staphylococcus aureus [J]. [28]. Methods: For the treatment, the main effects of Lianhua Qingwen Jiaonang capsuleare as follows: First, after taking the capsule, patients' symptoms improve quickly, recovery rate up to 91.5%, conversion to severe cases down to 2.1%. [Functions and Indications] Wu C, Chen X, Cai Y, et al. Heart or thyroid disease, high BP, diabetes, glaucoma, HTN, tumor of adrenal gland, difficulty in urination due to the enlargement of the prostate gland. Any disagreement will be resolved by consensus or discussion with a 3rd party (MJL). 6.Patients with fever over 38.5 , should go to the hospital. Study on the effect of Lianhuaqingwen Granule on BALB /c mice infected with respiratory syncytial virus [J]. Statistical heterogeneity will be assessed with the I2 statistic. [35]. Lianhua Qingwen 2023 Jan 12;17:11779322221149622. doi: 10.1177/11779322221149622. Available at: [30]. [Overview of Meta-analysis of Lianhua Qingwen preparations in treatment of viral diseases]. Efficacy and safety of Lianhua Qingwen combined with : Medicine In 2018, Diagnosis and Treatment Scheme for Influenza (2018), issued by the National Health and Family Planning Commission PMC Put this medicine beyond the childrens reach. Removes heat-toxin invasion of the lungs, including symptoms eg, fever, aversion to cold, muscle soreness, stuffy & runny nose. Careers. Hai Guo, Jin Yang, Jiening Gong, et al. to maintaining your privacy and will not share your personal information without In 2009, Diagnosis and Treatment Scheme for Patients Infected with Type A H1N1 Influenza (2009), issued by the State Administration of traditional Chinese medicine Its formulation includes 13 herbs which are said to have been used for medical purposes as early as the Han dynasty. Qi Luo Lun [M]. Recently, the novel coronavirus pneumonia (COVID-19) epidemic has spread continuously and has been classified as class B infectious diseases (class a management). BecauseLHQWhas multiple ingredients, other possible interactions with any of its ingredients could also occur. Biotechnology communication 2003;14:3902. [Administration and Dosage]For oral administration, 4 capsules once, 3 times daily. Pregnancy & lactation. We will perform the sensitivity analysis to explore the effects of trial risk of bias on primary outcomes if possible. Below dosage is a guide only. Aside from the Philippines, the Lianhua Qingwen Capsule has been approved in Hong Kong and Macau, Brazil, Indonesia, Canada, Mozambique, Romania, Thailand, Ecuador, Singapore and Lao. Zhang, Xiaolin MDa,; Cao, Di MMb; Liu, Junnan MMa,c; Zhang, Qi MDa; Liu, Mingjun PhDa,, aChangchun University of Chinese Medicine. Second Prize of National Science and Technology Progress Awards Even There is no effective antiviral drug for COVID-19. Exclusion: studies using two or more Chinese herbal compound as intervention measures will be excluded. Treatment of Pediatric Diseases, 2017, recognized as a recommended product in the Standard Therapy for Human Beings Infected by H7N9 Avian Influenza, 2016, the Phase II Clinical Trial for Lianhua Qingwen approved by US FDA started in Virginia in the US in September, 2015, recognized as a recommended product in the Expert Consensus Document on Treatment of Cold in Special Populations, 2015, recognized as a recommended product in the Standard Therapy for Middle East Respiratory Syndrome, 2014, recognized as a recommended product in the Standard TCM Therapy for Ebola Virus Infections, 2014, recognized as a recommended product in the Standard Therapy for Human Beings Infected by H7N9 Avian Influenza, 2013, recognized as a recommended product in the Expert Consensus Document on Medical Rescuing of Human Beings Infected by H7N9 Avian Influenza, 2013, recognized as a recommended product in the Standard Therapy for Human Beings Infected by H7N9 Avian Influenza, 2012, recognized as a recommended product in the Standard TCM Therapy for Influenza B Virus Infections, 2011, recognized as a recommended product in the Guideline on Diagnosis and Treatment of Influenza, 2010, recognized as a recommended product in the Standard Therapy for Rheumatic Fever (Non-severe Community Acquired Pneumonia), 2009, recognized as a recommended product in the Standard Therapy for Human Beings Infected by Influenza A H1N1, 2008, recognized as a recommended product in the Instructions on Use of TCM Therapies for Prevention and Treatment of Diseases after an Earthquake, 2008, recognized as a recommended product in the Standard Therapy for Human Beings Infected by Avian Influenza (2008), 2005, recognized as a recommended product in the Standard Therapy for Human Beings Infected by Avian Influenza, [Drug Name]Generic name: Lianhua Qingwen Capsules.
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